Journal article
The impact of early life exposure to Plasmodium falciparum on the development of naturally acquired immunity to malaria in young Malawian children
P Barua, JG Beeson, K Maleta, P Ashorn, SJ Rogerson
Malaria Journal | BMC | Published : 2019
Abstract
Background: Antibodies targeting malaria blood-stage antigens are important targets of naturally acquired immunity, and may act as valuable biomarkers of malaria exposure. Methods: Six-hundred and one young Malawian children from a randomized trial of prenatal nutrient supplementation with iron and folic acid or pre- and postnatal multiple micronutrients or lipid-based nutrient supplements were followed up weekly at home and febrile episodes were investigated for malaria from birth to 18 months of age. Antibodies were measured for 601 children against merozoite surface proteins (MSP1 19kD, MSP2), erythrocyte binding antigen 175 (EBA175), reticulocyte binding protein homologue 2 (Rh2A9), schi..
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Grants
Awarded by State Government of Victoria
Funding Acknowledgements
This work was supported by a grant from the Office of Health, Infectious Diseases, and Nutrition, Bureau for Global Health, U.S. Agency for International Development (USAID) under terms of Cooperative Agreement No. AID-OAA-A-12-00005, through the Food and Nutrition Technical Assistance III Project (FANTA), managed by FHI 360 and additional funding from a grant to the University of California, Davis from the Bill & Melinda Gates Foundation [Grant Number 49817] and the Academy of Finland [Grant Number 252075]. SJR and JGB are supported by a Program Grant from the National Health and Medical Research Council of Australia (NHMRC) [Grant Number 1092789], and NHMRC Senior Research Fellowship [to JGB; APP1077636]. The Burnet Institute is supported by an Operational Infrastructure Support grant from the Victorian State Government, Australia, and the NHMRC Independent Research Institute Infrastructure Support Scheme. PB is supported by Melbourne International Fee Remission Scholarship (MIFRS) and Melbourne Research Scholarship program.